"Weird Al" Yankovic guides the audience through a 3-D lesson on the human brain. Al answers "man on the street" questions, provides interesting trivia, and even recounts the unfortunate mishap of Phineaus Cage. The film ends with "The Brain Song," which details exactly how the brain works.

Cast

'Weird Al' Yankovic

Self / Phineas Gage

Billy West

Norm the Owl / Billy the Brain

Tim Heidecker

Brain Stretcher

Eric Wareheim

Brain Stretcher

Patton Oswalt

Co-Worker

Thomas Lennon

Co-Worker

Paul McCartney

Man on the Street

Fabio

Man on the Street

Bob Bancroft

Norm Kozlovsky

Ezra Buzzington

Homeless Guy