Mel Blanc

Barney Rubble / Dino / Mr. Spacely (voice)

Daws Butler

Elroy Jetson / W.C. Cogswell / Henry Orbit (voice)

Don Messick

Astro / R.U.D.I / Mac / Announcer / Store Manager / Robot (voice)

Henry Corden

Fred Flintstone / Knight (voice)

Hamilton Camp

Turk Tarpit (voice)

Julie McWhirter

Betty Rubble / Jet Rivers / Investor / Panelist / Harem Girl (as Julie Dees) (voice)

George O'Hanlon

George Jetson (voice)

Penny Singleton

Jane Jetson (voice)

John Stephenson

Mr. Slate / Moderator / Investor / Poker Player (voice)

Brenda Vaccaro

Didi (voice)

Jean Vander Pyl

Wilma Flintstone / Rosie / Mrs. Spacely (voice)

Janet Waldo

Judy Jetson / Female Computer (voice)